Fermentation Technology Massachusetts Institute of Technology (MIT)

Overview

What you will learn

The learning objectives of the Fermentation Technology course offered by Massachusetts Institute of Technology (MIT) are:

• Examine the application of biological and engineering principles to problems involving microbial, mammalian, and biological/biochemical systems.

• Recognize the fundamentals of fermentation technology.

• Describe current knowledge in biological and biochemical technology, with a focus on industrial practices.

• Comprehend growth and metabolism, genetics and metabolic engineering in the age of genomics, the biological basis for monitoring bioprocesses including process analytical technology, and applications of the modern biological concepts in bioprocess developments.

• Examine eukaryotic and prokaryotic protein expression relevant to industrial practice, including post-translational modifications (esp. protein glycosylation).

• Assess power requirements in bioreactors, modeling of bioprocesses, traditional and new concepts in bioprocess monitoring, and the biological basis for industrial fermentations and cell cultures.

• Distinguish bioreactor operations in bacteria and mammalian cell systems, oxygen transfer and shear in bioreactors, process improvement through metabolic manipulations, and scale-up of bioreactors such as bacterial, yeast, and mammalian cells.

• Analyze the bioprocess paradigm: Scale-down, bioprocess simulation and economics, sterilization, and bioburden in biological manufacturing.

• Examine considerations in bioprocess simulation and economics, sterilization in biological manufacturing, and clinical implications of bioprocesses.